This dataset consists of a quantitative imaging dataset of ZooScan-imaged mesoplankton and microplastics, collected with the Manta net (333 µm mesh size) aboard the schooner Tara during the Tara Pacific Expedition (2016-2018). Samples were collected at the surface across the Pacific Oceans from open-ocean stations (32 samples, open-ocean label: [i00_oa###]), with 28 samples located on the Great Pacific Garbage Patch, and from stations in coastal [...]