In the context of contamination of shellfish species by domoic acid produced by microalgal species of the genus Pseudo-nitzschia, we studied the particular case of depuration kinetics of king scallops, Pecten maximus. The study was based on the REPHYTOX dataset (https://doi.org/10.17882/47251) which includes, among others, long-term time series of domoic acid in shellfish species. We selected only the locations along the English Channel and the Atlantic coastline. Contamination events were defined for each locations, depuration rates were estimated fitting an exponential decay model using a non-linear least squares regression. Spatio-temporal variability was assessed as well as correlations to environmental conditions, using REPHY dataset (https://doi.org/10.17882/47248). Finally, scenarios for predictions of either the dynamics of depuration or the domoic acid contamination at a precise date were performed. Four files are available as data used for the study and results : (i) subset of REPHYTOX dataset, (ii) subset of REPHY dataset, used in this study and (iii) contamination event information (i.e., initial and end date of the event, initial domoic acid concentration) and depuration rate estimations, and (iv) predictions of depuration dynamics with different scenarios. Information on each file is detailed in the end user manual and methodology and results are linked to an article in preparation.